Received: 13 January 2021; Published on-line: 30 April 2022

Primary mesodermal dysgenesis of the cornea (Peter´s anomaly)

Leopoldo Garduño Vieyra, Dr.; Dr. Raúl Rúa Martínez, Dr.; Francisco Javier Rodríguez Hernández, Dr.; Isabel De la Fuente Batta, Dr.

Clínica Oftalmología Garduño; Irapuato, Guanajuato (México)

E-mail: ruamartinez@yahoo.es

TO CITE THIS ARTICLE: Leopoldo Garduño Vieyra, Raúl Rúa Martínez, Francisco Javier Rodríguez Hernández, Isabel De la Fuente Batta. Primary mesodermal dysgenesis of the cornea (Peter´s anomaly)J.ophthalmol.(Ukraine).2022;2:65-7.   http://doi.org/10.31288/oftalmolzh202226567


Primary mesodermal dysgenesis of the cornea, also known as Peter´s anomaly (PA) or keratolenticular dysgenesis, is a rare congenital eye condition caused by an abnormal development of the anterior segment. PA is characterized by unilateral or bilateral corneal opacity (leucoma), that appears since the early neonatal period. The incidence of PA in the United States of America is approximately 1.5 per 100,000 live births. PA is known as Peters-plus syndrome when it presents with systemic malformations. In this article we describe the clinical presentation of an 18-year-old patient with PA that arrived to medical consultation due to bilateral corneal opacities since birth. The patient´s parents refer that he has hypoacusis and deny other systemic pathologies. Clinical exploration reveals a visual acuity of 20/30 of the right eye and 20/100 of the left eye. According to the clinical findings and the absence of systemic anomalies, the patient was diagnosed with PA type II. 

Key words: сongenital, Peter´s аnomaly, leucoma, cataract


Acknowledgments: To all the staff of our clinic

Disclaimers: The authors remove any responsibility from the journal in relation to the content of this article.

Source(s) of support: The authors didn´t received extra monetary support for the realization of this article.

Disclosure of relationships and activities: The authors declare no conflict of interests.



1.Brobova N, Romanova T, Tronina SA. Successful Two-Stage Rehabilitation of The Ectodermal form of Peters Anomaly in Frakcaro-Schmid Syndrome. Ukr J Ophthalmol. 2011;6:49–52.


2.Demir GÜ, Lafcı NG, Doğan ÖA, Kiper PÖŞ, Utine GE. Peters plus syndrome: A recognizable clinical entity. Turk J Pediatr. 2020;62(1):136–40.

Crossref  PubMed 

3.Elbaz U, Strungaru H, Mireskandari K, Stephens D, Ali A. Long-Term Visual Outcomes and Clinical Course of Patients With Peters Anomaly. Cornea. 2020;00(00):1–9. 

4.Faber H, Puk O, Holz A, Biskup S, Voykov B. Identification of a New Genetic Mutation Associated With Peters Anomaly. Cornea. 2020;00(00):1–4. 

5.Karadag R, Rapuano CJ, Hammersmith KM, Nagra PK. Causes of congenital corneal opacities and their management in a tertiary care center. Arq Bras Oftalmol. 2020;83(2):98–102.

Crossref  PubMed

6.Kurilec JM, Zaidman GW. Incidence of peters anomaly and congenital corneal opacities interfering with vision in the united states. Cornea. 2014;33(8):848–50.

Crossref  PubMed 

7.Li Y, Zhang J, Dai Y, Fan Y, Xu J. Novel Mutations in COL6A3 That Associated With Peters’ Anomaly Caused Abnormal Intracellular Protein Retention and Decreased Cellular Resistance to Oxidative Stress. Front Cell Dev Biol. 2020;8(November):1–13.

Crossref  PubMed 

8.Samara A, Eldaya RW. Ocular and brain imaging findings in Peters’ anomaly: A case report and literature review. Radiol Case Reports. 2020;15(7):863–6.

Crossref  PubMed 

9.Walkden A, Au L. Iridocorneal endothelial syndrome: Clinical perspectives. Clin Ophthalmol. 2018;12:657–64.

Crossref  PubMed

10.Weigele J, Bohnsack BL. Genetics underlying the interactions between neural crest cells and eye development. J Dev Biol. 2020;8(4):1–24.

Crossref  PubMed


Authors approve the manuscript and agree with what is expressed in it and do not have conflict of interest in this article.


Received 19.01.2021