Офтальмол. журн. — 2022. — № 6. — С. 24-29.

УДК  617.7-02:616.13/14-002.151]-07


Ophthalmological involement and laboratory changes in patients with ANCA-associated vasculitis and polyarteritis nodosa

O. Iaremenko, Doctor of Medical Sciences, Professor; L. Petelytska, MD, PhD 

Bogomolets National Medical University; Kyiv (Ukraine)

ЯКЦИТУВАТИ: Iaremenko O. Ophthalmological involvement and laboratory changes in patients with anca-associated vasculitis and polyarteritis nodosa / O. Iaremenko, L. Petelytska // Офтальмол. журн. — 2022. — № 6. — С. 24-29. http://doi.org/10.31288/oftalmolzh202262429



Background.  Ophthalmic involvement (OI) is an early manifestation of systemic vasculitis and may lead to blindness.

Purpose. Aim of the study was to identify the frequencies and patterns of OI in patients with ANCA-associated vasculitis (AAV) and polyarteritis nodosa (PAN) and evaluate the laboratory changes depending on OI.

Material and Methods. This work included retrospective study (112 patients with PAN and 80 patients with AAV) and prospective cohort study, which evaluated serum levels of endothelin-1 (ET-1) in 36 patients and 26 healthy сontrols. 

Results. OI at diagnosis in AAV occurred 4 times more often compared to PAN and consisted of conjunctivitis/episcleritis (16% AAV patients), optic neuropathy (5% PAN patients), orbital mass, uveitis, scleritis, epiphora or dry eyes. OI was more commonly detected in PR3-ANCA(+) vs PR3-ANCA(-) patients. The levels of ET-1 were elevated in patients without OI compared with control group and patients with OI, but ability of ET-1 to differentiate such patients was poor. 

Conclusion. The most common OI in patients with AAV was episcleritis. Optic neuropathy was the only manifestation of OI in patients with PAN. OI were more commonly detected in PR3-ANCA(+) vs PR3-ANCA(-) patients. The serum levels of ET-1 were significantly elevated in patients without OI compared with patients with OI and control group, but its diagnostic value was not approved in the ROC analysis. 

Keywords: eye involvement, anti-neutrophil cytoplasmic antibody-associated vasculitis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, microscopic polyangiitis, polyarteritis nodosa



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Information about authors and disclosure of information

Corresponding author: Liubov Petelytska – l.petelytska@gmail.com.

Authors’ contributions: Oleg Iaremenko contributed to the idea for the article. Material preparation and data analysis were performed by Liubov Petelytska and Oleg Iaremenko. The first draft of the manuscript was written by Liubov Petelytska and Oleg Iaremenko commented on previous versions of the manuscript. Two authors read and approved the final manuscript.

Conflict of interest: The authors have declared that no competing interests exist.

Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Authors fulfilled the ICMJE authorship criteria.

Funding information: This research does not received specific grant from any funding agency in the public, commercial or not-for -profit sector. 


Received 28.08.2022