Received: 21 November 2019; Published on-line: 21 February 2020

A case of vascularized corneal opacity treated with aflibercept 

A.S. Cholak, MD; I.O. Nasinnyk, Cand Sc (Med); P.O. Kostenko, Cand Sc (Med); S.A. Iakimenko, Dr Sc (Med), Prof.; A.R. Korol, Dr Sc (Med)

Filatov Institute of Eye Diseases and Tissue Therapy, National Academy of Medical Science;  Odesa (Ukraine)

E-mail:  anastasiakrivoruchko2593@gmail.com

TO CITE THIS ARTICLE: Cholak AS, Nasinnyk IO, Kostenko PO, Iakimenko SA, Korol AR.  A case of vascularized corneal opacity treated with aflibercept. J.ophthalmol.(Ukraine).2020;1:54-56. http://doi.org/10.31288/oftalmolzh202015456



Background: Corneal neovascularization (CNV) is a serious condition that can lead to a profound decline in vision. Current research on treating CNV with angiogenesis inhibitors is underway in numerous centers, and a number of studies have demonstrated the efficacy of this approach.

Purpose: To present a case of corneal neovascularization treated with aflibercept.

Material and Methods: An ocular examination included visual acuity assessment, biomicroscopy, anterior eye photography and fluorescein angiography (FA). In addition, an area of CNV was assessed before and 6 months after a single subconjunctival injection of 4 mg (0.1ml) aflibercept.

Results:  An area of CNV decreased from 38,081 pixels before injection to 20,782 at 6 months, with a reduction in 17,299 pixels.

Conclusion: In the case reported here, a single subconjunctival injection of 4 mg (0.1ml) aflibercept was found to be effective for reducing corneal neovascularization at 6 weeks.

Keywords:  corneal neovascularization, fluorescein angiography, angiogenesis inhibitor, aflibercept



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The authors certify that they have no conflicts of interest in the subject matter or materials discussed in this manuscript.