Oftalmol Zh.2015;2;16-21


The state of tear production in conjunctival-corneal cicatricial xerosis of the eye and possibility of its treatment

S.A .Yakimenko, Dr.Sc ( med) , prof., Amjad Albin, a postgraduate student

SI "The Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine "; Odessa, Ukraine

E-mail: ojohi glaz@te.net.ua

The paper presents the results of the study of tear production in patients with the most severe form of the dry eye syndrome - cicatricial xerosis of the eye, depending on the size of the formed symblepharons including both before and after their elimination. It was found that the removal of the eyelid scar adhesions with the eyeball by transplanting mucous lips does not improve tear production and prevents its progression.

A comprehensive treatment with application of anti-inflammatory, dedystrophic, preparations stimulating regeneration and antioxidant drugs tear substituting drugs slightly improves visual acuity of such eyes.

The application of obturators or diathermocoagulation of the lacrimal points slightly improves hydration of the eye. It is shown that the only possible method of vision restoration of patients with cicatricial xerosis of the eye is keratoprosthesis with a preliminary consolidation of the cornea of the mucous lips.

Keywords: conjunctival-corneal cicatricial xerosis, keratoprosthesis.


  1. Brzheskii VV, Somov EE. Dry eye syndrome. SPb.: Apollon; 1998. 96 p. 
  2. Drozhzhina GI. Modern methods for treatment of dry eye syndrome. Oftalmol Zh. 2013;5:3–9. In Russian. 
  3. Kanski JJ. Clinical ophthalmology. Translated from English. M.; 2002. 
  4. Legeza GV. Results of surgical treatment of extensive and complete symblepharon in the presence of the eyeball. Oftalmol Zh. 1956;4:225. In Russian. 
  5. Puchkovskaia NA. Surgical treatment of extensive and complete symblepharon. Vestn Oftalmol. 1951;4–6. In Russian. 
  6. Puchkovskaia NA, Yakimenko SA, Nepomyashchaia VM. Eye burns. M.: Meditsina; 2001. 272 p. In Russian. 
  7. Samsonova VA, Znamenskaia LF, Kurovskaia TA, Yurasov SN. Scarring pemphigoid with multiple lesions of the skin and mucous membranes. Vestn. Dermatologii I Venerologii. 2008;6:82–4. In Russian. 
  8. Sultanov IYa, Ovchinnikova LV, Gustova AV. Stevens-Johnson syndrome. Vestnik RUDN. Meditsina; 2010;1:137–40. In Russian. 
  9. Chicherina EN, Malykh SV, Akshentsyva MV. Lyell’s syndrome (Clinics, diagnostics, modern methods of treatment). Vyatskii Med. Vestnik. 2008;3–4:15–9. In Russian. 
  10. Shevalev VE. Cicatricial xerosis of the eye. Kiev;1959. 175 p. 
  11. Yakimenko SA. Retrospective analysis of the development and application of the results of keratoprosthetics at the Filatov Institute for 40 years. Oftalmol Zh. 2006;6:63–8. In Russian. 
  12. Elizabeth Shay, Ahmad Kheirkhah, Lingyi Liang et al. Amniotic Membrane Transplantation as a New Therapy for the Acute Ocular Manifestations of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Surv Ophthalmol. 2009;54 (6):686–96. 
    Crossref   Pubmed
  13. Jessica B Ciralsky, Kimberly C Sippel. Prompt versus delayed amniotic membrane application in a patient with acute Stevens-Johnson syndrome. Clinical Ophthalmology. 2013;7:1031–4. 
    Crossref   Pubmed
  14. Kruszka P, O’Brian R. J. Diagnosis and management of Sjogren syndrome. Am Fam Physician. 2009;79:465–70. 
  15. Tan JC, Tat LT, Francis KB et al. Prospective Study of Ocular Manifestations of Pemphigus and Bullous Pemphigoid Identifies a High Prevalence of Dry Eye Syndrome. Cornea. 2015, Feb 3. [Epub ahead of print]. 
    Crossref   Pubmed