J.ophthalmol.(Ukraine).2019;4:38-42.

http://doi.org/10.31288/oftalmolzh201943842

The immune status of patients with frontal bone trauma with implant SYNTEKIST used in surgical treatment

О.D.Bondarchuk1,2, V.V. Kishchuk1, О.F. Melnykov3, М.D. Tymchenko3, N.D. Didyk2

1 Mykola Pyrohov Vinnytsia National Medical University; Vinnytsia (Ukraine)

2 Mykola Pyrohov Vinnytsia Regional Hospital; Vinnytsia (Ukraine)

3 Prof. O.S. Kolomiychenko Otolaryngology Institute of NAMS; Kyiv (Ukraine)

E-mail:  eskulap20009@gmail.com

TO CITE THIS ARTICLE: Bondarchuk ОD, Kishchuk VV, Melnykov ОF, Tymchenko МD, Didyk ND. The immune status of patients with frontal bone trauma with implant SYNTEKIST used in surgical treatment. J.ophthalmol.(Ukraine).2019;4:38-42. http://doi.org/10.31288/oftalmolzh201943842

 

Aim. To determine the influence of a biocomposite on the state of the immune system of patients with trauma to the frontal bone at 1 month after surgical treatment. 

Materials and Methods. 20 patients with frontal bone fracture treated surgically with and without a SYNEKIST biocomposite were examined; 10 patients served as control. Immunoglobulins M, G, A, and E were determined in the blood serum using enzyme-linked immunosorbent assay. We also determined the content of prodefensin (lactoferrin, an indicator of the acute phase of inflammation), interleukins IL-1β, and interleukin-10.

Results. On presentation and during the first days, the patients with trauma to the frontal bone had a decreased level of IgM which, however, reached the control level and was practically the same in both groups. There were no changes in other immunoglobulins in a month. The level of pro-inflammatory Il-a was increased on admission with a significant decrease within the first month in both treatment approaches. The on-admission level of pro-inflammatory cytokines did not differ significantly from the control while its level increased in the patients undergone the surgical treatment using a biocomposite material. The level of lactoferrin decreased to normal ranges in both treatment approaches.

Conclusions. The advantage of the surgical treatment using a biocomposite material lies in the restoration of the IgM level and activation of anti-inflammatory mechanisms, Il-10, in particular, in 1 month. 

Keywords: trauma to the frontal bone, immunoglobulins, interleukins, biocomposite SYNTEKIST

 

References:

1.Gubler ЕV. [Informatics in pathology, clinical medicine and pediatrics]. L.: Medtsyna; 1990. 176 p. In Russian

2.Drannik GN. [Clinical immunology and allergology]. Kiev: Astra Print Ltd; 2006. 480 p. In Ukrainian.

3.Kishchuk VV, Bondarchuk OD. [Using biocomposites „Syntekist” to liquidate bone defects of ENT-organs]. Zhurnal vushnykh, nosovykh i horlovykh khvorob. 2007;5c:43-4. In Ukrainian. 

4.Lysianyi NI, Pedachenko EG. [The peculiarities of autoimmune reactions’ development during recurring TBI]. Imunologiia ta alergologiia. 2006;3:53-6. In Russian. 

5.Jäger C, Welzel T, Meyer-Zaika W, Epple M. A solid-state NMR investigation of the structure of nanocrystalline hydroxyapatite. Magn. Reson. Chem. 2006 Jun;44(6):573–80. 

6.Jager L. Clinical immunology and allergology. М: Medicine. 1986;3:344-64.

7.Wu Y, Ackerman JL, Kim HM, Rey C, Barroug A, Glimcher MJ. Nuclear magnetic resonance spin-spin relaxation of the crystals of bone, dental enamel, and synthetic hydroxyapatites. J Bone Miner Res. 2002 Mar;17(3):472-80 p. 

8.Avtandilov GG. [Basics of quantitative pathological anatomy]. M.: Meditsyna; 2006. 240 p. In Russian

9.Anikin IA, Bykova VP, Patjakina OK, Portenko EG. [Сondition of the lining in trepanation cavity after radical surgery on the middle ear according to histological research. Vestnik otorinolaringologii]. 1998;1:10–4. In Russian.

10.Dydenko VY, Kokorkyn DN, Husakova AA. [Autotransplantation of spongy autologous bone with marrow during reconstructive-plastic surgery of postoperative cavities in the temporal bone. Surgical technique of autograft collection and his preparation for autotransplantation]. Zhurnal vushnykh, nosovykh i horlovykh khvorob. 2007;6: 57–8. In Ukrainian.

11.Nikolaev NP, Mihajlenko NJu, Stroganova EE, Purjasev AS. Biocitalls as new materials for implantology in otorhinolaryngology. Rossijskaja otorinolaringologija. 2005;5:139–42. In Russian

12.Porushnyk YeP, Ivanchenko AA, Brusko AT. [Biocompatibility with bone tissue and osteotropy of composite materials based on biologic hydroxyapatite]. Problemy osteolohii. 2000; 3(4):89. In Ukrainian.

13.Kim HM, Himeno T, Kokubo T, Nakamura T. [Process and kinetics of bone like apatite formation on sintered hydroxyapatite in a simulated body fluid]. Biomaterials. 2005;26(2):4366–73. 

14.Voloshina IA, Hamzalieva RB. [Mortality rate with othogenic and rhinogenic intracranial complications]. Vestnik otorinolaringologii. 2009;1:23–5. In Russian.

15.Semenov FV, Gorbonosoe IV, Starikov AV, Rianenko VA. [The use of glass-ceramic granules biosite-elkor to reduce the volume of trepanation cavity during operations on the middle ear]. Vestnik otorinolaringologii. 2005;1:32–5. In Russian.

16.Zabolotnyi DI, Kishchuk VV, Bondarchuk OD, Dmytrenko IV. Method of surgical treatment in patients with acute period of craniocerebral trauma of front-basal localization. Zhurnal vushnykh, nosovykh i horlovykh khvorob. 2013;6:80-3. In Ukrainian.

 

The authors certify that they have no conflicts of interest in the subject matter or materials discussed in this manuscript.