The immune status of patients with frontal bone trauma with implant SYNTEKIST used in surgical treatment

О.D.Bondarchuk1,2, V.V. Kishchuk1, О.F. Melnykov3, М.D. Tymchenko3, N.D. Didyk2

1 Mykola Pyrohov Vinnytsia National Medical University; Vinnytsia (Ukraine)

2 Mykola Pyrohov Vinnytsia Regional Hospital; Vinnytsia (Ukraine)

3 Prof. O.S. Kolomiychenko Otolaryngology Institute of NAMS; Kyiv (Ukraine)

E-mail:  eskulap20009@gmail.com

TO CITE THIS ARTICLE: Bondarchuk ОD, Kishchuk VV, Melnykov ОF, Tymchenko МD, Didyk ND. The immune status of patients with frontal bone trauma with implant SYNTEKIST used in surgical treatment. J.ophthalmol.(Ukraine).2019;4:38-42. http://doi.org/10.31288/oftalmolzh201943842


Aim. To determine the influence of a biocomposite on the state of the immune system of patients with trauma to the frontal bone at 1 month after surgical treatment. 

Materials and Methods. 20 patients with frontal bone fracture treated surgically with and without a SYNEKIST biocomposite were examined; 10 patients served as control. Immunoglobulins M, G, A, and E were determined in the blood serum using enzyme-linked immunosorbent assay. We also determined the content of prodefensin (lactoferrin, an indicator of the acute phase of inflammation), interleukins IL-1β, and interleukin-10.

Results. On presentation and during the first days, the patients with trauma to the frontal bone had a decreased level of IgM which, however, reached the control level and was practically the same in both groups. There were no changes in other immunoglobulins in a month. The level of pro-inflammatory Il-a was increased on admission with a significant decrease within the first month in both treatment approaches. The on-admission level of pro-inflammatory cytokines did not differ significantly from the control while its level increased in the patients undergone the surgical treatment using a biocomposite material. The level of lactoferrin decreased to normal ranges in both treatment approaches.

Conclusions. The advantage of the surgical treatment using a biocomposite material lies in the restoration of the IgM level and activation of anti-inflammatory mechanisms, Il-10, in particular, in 1 month. 

Keywords: trauma to the frontal bone, immunoglobulins, interleukins, biocomposite SYNTEKIST



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The authors certify that they have no conflicts of interest in the subject matter or materials discussed in this manuscript.