J.ophthalmol.(Ukraine).2019;2:44-49.
http://doi.org/10.31288/oftalmolzh201924449
Received: 20 March 2019; Published-online: 24 April 2019
Study of etiologic factors for optic atrophy
V.A. Vasyuta,1 Dr Sc (Med); Yu.E. Pedachenko,2 Dr Sc (Med), Ass Prof
1 Romodanov Neurosurgery Institute, National Academy of Medical Science of Ukraine; Kyiv (Ukraine)
2 Shupik National Medical Academy of Postgraduate Education; Kyiv (Ukraine)
E-mail: Vasyuta.v@ukr.net
TO CITE THIS ARTICLE: Vasyuta VA, Pedachenko YuE. Study of etiologic factors for optic atrophy. J.ophthalmol.(Ukraine).2019;2:44-9. http://doi.org/10.31288/oftalmolzh201924449
Background: Optic atrophy (OA) is a disease of multiple etiologies and is a consequence of various pathological changes along the optic pathway. Central nervous system (CNS) disorders, vascular impairments and retinal and optic nerve diseases are important in the etiology of this condition.
Purpose: To investigate various etiologic factors for OA.
Materials and Methods: Patients were retrospectively divided into three groups: Group 1 (primary descending OA; 2,046 patients); Group 2 (primary ascending OA; 430 patients); and Group 3 (secondary OA; 190 patients).
Results: Supratentorial tumors prevailed (78.0-79.4%) among the neurosurgical disease causing optic atrophy. Vascular factor was the most common cause (27.6-28.5%) of ascending OA, followed by inflammatory (25.5-30.1%). We found the presence of essential hypertension, diabetes mellitus type 2, and atherosclerosis to be significant medical risk factors for OA, with odds ratios of 2.46 (95% CI = 1.69 to 3.58), 2.32 (95% CI = 1.22 to 4.41), and 2.11 (95% CI = 1.41 to 3.15), respectively.
Keywords: optic nerve, atrophy, etiology
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The authors certify that they have no conflicts of interest in the subject matter or materials discussed in this manuscript.