Features of the course and treatment of JIA-associated uveitis
M.V. Panchenko,1 Dr Sc (Med); N.S. Shevchenko,2,3 Dr Sc (Med); M.V. Demianenko,3 MD; Honchar O.M., 1 Cand Sc (Med); L.G. Avilova,1 MD
1 Kharkiv National Medical University
2 Karazin Kharkiv National University
3 Pediatric and Adolescent Health Institute of the NAMS of Ukraine;
Purpose: To investigate the features of the clinical course of and the state of eye care for patients with juvenile idiopathic arthritis (JIA)-associated uveitis (JIA-U).
Materials and Methods: We analyzed the results of monitoring 121 patients aged 7 to 18 years with JIA. Twenty one (17.35%) of these had uveitis.
Results: In 17 (80.95%) of the examined JIA-U patients, JIA onset age was younger than 6 years, and mean JIA onset age was significantly younger than in JIA patients without uveitis (2.89±0.26 years vs 6.43±0.4 years, р<0.05). Most (85.7%) JIA-U patients were asymptomatic. Chronic keratic precipitates and posterior synechiae were found in 38.09% and 42.85%, respectively, of cases. Uveal cataract was the most common complication (57.14%), followed by corneal degeneration (33.33%), macular edema (28.57%), ocular hypertension/ secondary glaucoma (19.05%), optic nerve edema (14.28%), hypotony (14.28%), vitreous fibrosis (9.52%), and retinal detachment (4.76%). The frequency of administration of biologics was 57.14%. The mean time from disease onset to administration of biologics in our JIA-U patients (2.67±0.79 years) was 2.5 times less than the value for JIA-U patients from all over Ukraine (6.9 years), indicating that biologics were timely administered.
Conclusion: Patients with the condition are commonly asymptomatic and have frequent ocular complications, with uveal cataract being the most common, followed by corneal degeneration and macular edema.
Keywords: uveitis, juvenile idiopathic arthritis
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The authors certify that they have no conflicts of interest in the subject matter or materials discussed in this manuscript.