Spectroscopic analysis of intraocular fluid in patients with cataract and pseudoexfoliation syndrome-associated glaucoma
P.A. Bezditko,1 Dr Sc (Med), Prof.; V.O. Melnyk,2 Cand Sc (Med); S.V. Kolotilov,3 Dr Sc (Chem)
1 Kharkiv National Medical University; Kharkiv (Ukraine)
2 Visiobud+ Clinic LLC; Kyiv (Ukraine)
3 Pisarghevskiy Institute of Physical Chemistry of NAS of Ukraine; Kyiv (Ukraine)
Background: Pseudoexfoliation syndrome (PES) is a risk factor for the development of primary open angle glaucoma (POAG). Impaired intraocular fluid (as reflected by the chemical composition and physical properties, velocity and viscosity, of this fluid) is a major factor for elevated intraocular pressure (IOP).
Purpose: To assess anterior eye characteristics and intraocular fluid protein levels in patients with PES and to compare them with those in patients with glaucoma and patients with cataract only.
Materials and Methods: We assessed anterior eye characteristics (anterior chamber depth and crystalline lens size) and protein levels in the intraocular fluid obtained intraoperatively during lens exchange in patients with PES. These data were compared with those of patients with glaucoma and patients with cataract only.
Results: The changes in anterior eye characteristics and intraocular fluid protein levels in patients with cataract plus PES were similar to those in patients with glaucoma, but not to those in patients with cataract without PES.
Conclusion: Study findings advocate for early surgical cataract extraction to avoid the development of glaucoma in patients with PES.
Keywords: open angle glaucoma, pseudoexfoliation syndrome, anterior chamber depth, crystalline lens size, spectroscopy of the intraocular fluid
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The authors certify that they have no conflicts of interest in the subject matter or materials discussed in this manuscript.