J.ophthalmol.(Ukraine).2018;6:35-39.

http://doi.org/10.31288/oftalmolzh201863539

Received: 10 September 2018; Published on-line: 31 December 2018


Characteristics of crystallographic changes in tear in different stages of diabetic retinopathy

I.M. Bezkorovayna, Dr Sc (Med), Prof.; D.O. Nakonechnyi; A.O. Bezkorovayna 

Ukrainian Medical Stomatological Academy;   

Poltava (Ukraine)

E-mail: nakone4nyiden@gmail.com

 

Introduction. Studying the specific crystallographic signs of tear in the development of diabetic retinopathy is of an extraordinary interest in clinical practice. 

Aim. To study the changes in the crystollografic signs of tear depending on a stage of diabetic retinopathy. 

Materials and methods. Under our supervision, there were 84 patients (145 eyes) with diabetes mellitus. Patients were divided into three groups according to the classification of diabetic retinopathy by N.V. Pasechnikova and V.O. Naumenko, adopted by the XII-th Ukrainian Congress of Ophthalmologists. Group 1 consisted of 36 patients (58 eyes) with non-proliferative diabetic retinopathy (NPDRP); Group 2 consisted of 25 patients (42 eyes) with pre-proliferative diabetic retinopathy (PPDRP); Group 3 consisted of 23 patients (45 eyes) with proliferative diabetic retinopathy (PDRP). 

Results. A vast intermediate area and single point inclusions in the amorphous and intermediate areas of the tear facie was noted in 81% of the NPDRP patients (р<0.01); the pathologic crystallization in the amorphous area of the tear facie and a prevalence of large-size crystals and vast intermediate areas was in 74% of the PPDRP patients (р<0.01);  and the increased density of crystal arrangement and single brown crystals were in 93% of the PDRP patients (р < 0.01).

Conclusions. A relationship was defined between the changes in  the tear crystallography type in the patients with PPDRP and PDRP, who had a crystollogram of type 3 and type 4, respectively, (p <0.01). The additional crystallographic sings of tear, the changes in which correspond to different stages of DRP, were also defined.

Keywords: diabetic retinopathy, native crystallography of tears, specific crystallographic sings

 

References

1.Bezkorovayna IM, Voskresenska LK, Riadnova VV, Shatkun AA. [Clinical features of changes in the retina depending on a type of diabetes mellitus]. Vrachebnoie delo. 2016;7–8(1140):104-8. Ukrainian. 

2.Brzheskii VV, Somov EE. [Tear fluid as a biological material for diagnostic testing]. [Current issues of pediatric ophthalmology: Proceedings]. SPb:1995;28-31. Russian.   

3.Zavgorodnyaya, NG, Isakova OA. [Early diagnosis of the syndrome of "dry eye" to assess the qualitative composition of tears]. Oftalmol  Zh. 2005;5:18-20. Russian.

4.Zavgorodnyaya NG, Brizhan AA. [Cytologic status changes of the conjunctiva and tears qualitative composition in patients with «dry eye» syndrome after instillation of modern topical fl uoroquinolones]. Zaporozhskii med. zhurnal. 2014;3(84):52-8. Russian.

5.Moshetova LK, Volkov OA. [A contemporary view of tear fluid, its role in diagnostics]. Klinicheskaia oftalmologiia. 2004;5(4):138-9. Russian.  

6.Pasechnikova NV, Naumenko VA, Zborovskaya AV, Kushnir NN, Yakovenko TA. [State of hematoretinal barrier in diabetic retinopathy according to the data of fluorometry]. Oftalmol Zh. 2008;5:4-7. Russian. 

7.Shabalin VN, Shatokhina SN et al. [Morphology of liquid fluids of the eye]. M.: Meditsina; 2004. 243 p. Russian.  

8.International Diabetes Federation. Available from: http://www.idf.org/diabetesatlas. 

9.Grus FH, Augustin AJ, Evangelou NG, Toth-Sagi K. Analysis of tear-protein patterns as a diagnostic tool for the detection of dry-eyes in diabetic and non-diabetic dry-eye patients. Eur J Ophthalmol. 1998;8(2):90-7.
Crossref   Pubmed

10.Richard G. Fluorescein and ICG angiography. Thieme Medical Publishers, Inc., New York; 1998. 369 p.

11.Walker J, Rykov SA, Suk SA, Saksonov SG. [Diabetic retinopathy: in a simple way about a complex thing].Kyiv;2013. 320 p. Russian.