Changes over treatment in total clinical symptom scores in patients with traumatic keratitis

V.M. Sakovych1, Dr Sc (Med), Prof., T.O. Ostrikova2, Ophthalmologist

1  Dnipropetrovsk Medical Academy at the Health Ministry of Ukraine,  Dnipro (Ukraine)

2 Dnipropetrovsk Clinical Hospital for Railway Employees, Branch of the PJSC Ukrzaliznytsia’s Healthcare Center Dnipro (Ukraine)

E-mail:  ostrikovatana@gmail.com                         

Background:  Since corneal tissue hypoxia develops in patients with traumatic keratitis, investigation of changes over treatment in clinical symptom scores in patients with traumatic keratitis undergoing adjunctive hyperbaric oxygenation (HBO) is of practical value.

Purpose: To investigate changes over treatment in clinical symptom scores in patients with traumatic keratitis undergoing adjunctive HBO.

Material and Methods: Sixty-nine patients (69 eyes; age, 18 years to 75 years) with traumatic keratitis were included in this study. Patients of the HBO group (33 eyes) received HBO therapy including 40-minute daily sessions in the OKA HBO chamber (operating in the 1.2 ATA mode) for 6 to 10 days as an adjunct in a comprehensive program of keratitis care. Changes over treatment in clinical symptom scores were investigated using the scale we developed.

Results: By the end of treatment, in the HBO group, the total mean clinical symptom score was 39.4% lower, and mean scores related to corneal fluorescein staining, corneal edema, inflammatory conjunctival injection and inflammatory infiltration were 40%, 59.09%, 18.2%, and 40%, respectively, lower than in controls (p < 0.01). At the end of treatment, mean BCVA in the HBO group was 30.51% higher than in controls (p < 0.001).

Conclusion: The use of adjunctive HBO contributed to substantial improvements in clinical symptom scores and BCVA in patients with traumatic keratitis.

Keywords: traumatic keratitis, adjunctive hyperbaric oxygenation


1.Gundorova RA, Stepanov AV, Kurbanova NF. [Current ophthalmic traumatology]. Moscow: Meditsina, 2007. Russian.

2.Chudniavtseva NA. [Restorative treatment of patients with eye traumas complicated by iridodialysis]. Oftalmol Zh. 2010;1:102-5. Russian.

3.Petrunia AM, Faruk IS. [Efficacy of lypophlavon in the comprehensive treatment for traumatic keratitis]. Oftalmol Zh. 2006;3:102-4. Russian.

4.Sakovich VN, Nikitchina TS, Shcherbakov BD. [Use of phlogenzym in the treatment for herpetic keratitis]. Oftalmologiya. Vostochnaya Evropa. 2012;2:141-5. Russian.

5.Gusova MK. [Toxic damage to the optic nerve secondary to alcohol intoxication]. [Abstract of Cand Sc (Med) Thesis]. Moscow: Russian Medical Postgraduate Education Academy; 2008. 15 pp. Russian.

6.Eliseeva EV. [Hyperbaric oxygenation in ophthalmology: Tutorial]. Karaganda; 2010. Russian.

7.Kuz’minov OD, Lukich VI. [Use of HBO in ophthalmology]. Bul. hiperbaricheskoi biologii I meditsiny. 2001;1-4:76-85. Russian

8.Znamenskaia MA, Rykov SA. [Herperic eye injuries]. In: Znamenskaia MA, editor.  [TORCH infections in obstetrics and neonatal care]. Kyiv: Standart Digital Print; 2008. Russian.

9.Beda DI. [Age-related macular degeneration management including the use of hyperbaric oxygenation]. [Abstract of Cand Sc (Med) Thesis]. Krasnoyarsk: State Medical Academy; 2010. 118 pp. Russian

10.Verkman AS. Role of aquaporin water channels in eye function. Exp Eye Res. 2003 Feb;76(2):137-43.
Crossref   Pubmed

11.Wilson SE, Mohan RR, Mohan RR, et al. The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res. 2001;20:625-37.
Crossref   Pubmed