Outcomes of accelerated corneal collagen cross-linking in keratoconus

Drozhzhyna G.I., Dr. Med. Sc., Prof.; Troychenko L.F., Cand. Med.Sc.; Naumenko V.A., Dr. Med. Sc., Prof.; Ivanova O.N., Cand. Med.Sc.; Sereda E.V.

SI “The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine”;

Odessa (Ukraine)

E-mail:  cornea@te.net.ua                        

Keratoconus (KC) is a degenerative noninflammatory disease of the cornea which is characterized be structural changes in the cornea which leads to progressive thinning and bulging in the central and/or peripheral part of the cornea and is accompanied by irregular astigmatism and significant vision impairment.

Today, keratoconus treatment is focused on a stage of disease development. At progressive KC stages (II-III), corneal collagen cross-linking is performed. At the present, a latest-generation unit (UV-X™2000, Avedro) is used to perform accelerated cross-linking, which allows for a threefold decrease of the procedure duration (to 10 minutes) compared to the standard protocol

Material and Methods. Corneal collagen cross-linking was performed in 71 patients (100 eyes). 

Results. Accelerated corneal collagen cross-linking for keratoconus stages II-III made it possible to stabilize the pathological process in 100% of cases, based on 12 month follow-up. Keratoconus stabilization was accompanied by: a decrease of astigmatism by 1.4 D and of the corneal refractive power by 3.2D; an increase of the corneal thickness by 8.8 nm; an increase of UCVA and BCVA in 96.5% and 89.6% of cases, respectively; and recovery of normal corneal architectonics according to confocal biomicroscopy data.  Subjectively, 64 patients (90%) noted the improvement in the vision quality and better tolerance to spectacles correction.

Key-words: keratoconus, corneal collagen, accelerated cross-linking