Cellular and humoral immunity in patients with varying clinical course localization uveitis
N. V. Konovalova, Shaibi Abderrahim
SI «Institute of Eye Diseases and Tissue Therapy V. P. Filatov NAMS of Ukraine»; Odessa (Ukraine)
Introduction. Uveitis, inflammatory diseases of the eye being in 25 % of cases result in disability-free, that determines the significance and relevance of the study of the pathogenesis of this disease.
The aim. Explore the direction and intensity of changes in the parameters of the tissue and humoral immunity in patients with uveitis with different clinical signs.
Materials and methods. In 61 patients with uveitis (46 pers. with lesions posterior segment of the eye, 15 — front, among whom 51 people was of chronic disease, and 10 — acute) were examined using standard ophthalmic methods. In the blood plasma parameters of cell studied (T-lymphocytes, T-helpers and T-suppressors) and humoral (B-lymphocytes, immunoglobulins A, M, G) immunity.
The results. The role of tissue and humoral immunity in the development of uveitis based on the clinical course of the inflammatory process. Shown a significant increase in the relative content of cytotoxic T lymphocytes and decrease in the index T helper/cytotoxic T-lymphocytes in the localization of uveitis in the posterior segment of the eye. In the acute phase of the process found a significant increase in the relative content of CD3 + and immunoregulatory index. Among the studied parameters of humoral immunity was significantly significant increase in the total-lymphocytes due to lower levels of Ig A in patients with posterior localization of uveitis. Significant differences between the level of the studied parameters of humoral immunity in patients with ostnym and chronic uveitis were found.
Conclusions. These results indicate that implementation of an immune response associated with uveitis, primarily with the activation of T-cell immunity, as well as the killer ability of natural killer cells.
Key words: uveitis, cellular and humoral immunity.
- Glants S. Medical and biological statistics. Translated from English. M.: Praktika;1998. 459 p.
- Gluzman DF, Sklyarenko LM, Nadgornaia VA, Kryachok IA. Diagnostic immunocytochemistry of tumors. Kiev:Morion; 2003. 6–15.
- Guliieva M. Experimental and clinical studies of eye drops ophthalmoferon in the treatment of herpetic keratitis. Author’ thesis for Candidate of Med. Science. 14.00.08 Ophthalmology. M.; 2006. 30 p.
- Degtyarenko TV. Adaptive significance of immune homeostasis in eye diseases. Oftalmol Zh. 1997;1:1–4. In Russian.
- Drozdova EA, Tarasova LN, Teplova SN, Alekhina TV. Immunological features of uveitis in systemic diseases. Vestn Oftalmol. 2004;4:24–6. In Russian.
- Zainutdinova GKh, Malkhanov VB, Shevchuk NE. Features of systemic and local cytokine production in rheumatoid uveitis. Tsitokiny i vospaleniie. 2008;7(2):52–5. In Russian.
- Frimel Kh, the Editor. Immunological methods. M.: Mir; 1979. 518 p.
- Metelitsyna IP, Levitska GV, Ghaffari Sahbi ben Mohamed Moncef. The level of cytokines in intraocular fluids in patients with rhegmatogenous retinal detachment. Odeskyi Med. Zhurnal. 2011; 4(126):37–9. In Ukrainian.
- Sukhina LA, Lysenko AG, Yulish ME. Optimizing the diagnosis and treatment of chronic recurrent uveitis in children caused by persistent intracellular infections. Oftalmologiia. Vostochnaia Evropa. 2014;2(21):20–6. In Ruaaian.
- Khokkanen VM, Solovieva MV, Bataiev VM, Ionova OG. Investigation of the role of cytokines in the course of tuberculous uveitis. Collection of papers of scientific practical conference in ophthalmosurgery «East-West», 13–14 May 2011. Ufa, 2011. 350–352. In Russian.
- Shaimova VA. The role of inflammatory cytokines in eye diseases. (Litereature review). Oftalmokhirurgiia i terapiia. 2004;4(3):30–2. In Russian.
- Groot — Mijnes JDF, Visser L, Zuurveen S et al. Identification of new pathogens in the intraocular fluid of patients with uveitis. Am. J. Ophthalmol. 2010;150 (5):628–36.
- Plskova J, Greiner K, Forrester JV. Interferon-? as an effective treatment for noninfectious posterior uveitis and panuveiti. Am. J. Ophthalmol. 2007;144:55–61.
- Takase H, Sugita S, Taguchi C et al. Capacity of ocular infiltrating T helper type 1 cells of patients with non — infectious uveitis to produce chemokines . Br. J. Ophthalmol. 2006;90:765–8.