Received: 24.10.2022; Accepted: 10.11.2022; Published on-line: 12.12.2022

Efficacy of exenteration of the orbit and sinus in malignant tumors of the ethmoidal labyrinth

F. D. Yevchev1, A. F. Yevcheva1, V. V. Gaevsky1, S. I. Poliakova2 

1Odesa National Medical University

2SI “The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine”

E-mail: Dr.Yevchev@ukr.net

Background: Diagnosing malignant tumors of the ethmoidal labyrinth early, with advanced techniques, is important, because late diagnosis may lead to intracranial spread to the eye or base of the skull.

Purpose: To assess the efficacy of exenteration of the orbit and sinus in the presence of the tumor of the ethmoidal labyrinth spreading to the eye.

Material and Methods: Sixty-two patients with a malignant tumor of the ethmoidal labyrinth spreading to the eye received surgery during 2017 through 2022. Of these, 42 (75.8%) were females and 20 (32.2%) were males, with patient age ranging from 55 to 75 years. Diagnostic assessment included computed tomography (CT) of the paranasal sinuses and orbit and tumor biopsy from the nasal cavity. Patients underwent a radical surgical procedure, an exenteration of the orbit and sinus. One month after surgery, they received preventive radiotherapy, with a dose of 40-45 Gy applied to the bed of the primary tumor.

Results: Intraoperative course was unremarkable, and no postoperative complications were found. All the patients (100%) showed no evidence of tumor recurrence or regrowth and no metastasis over a 6-month and 3-year follow-up.

Conclusion: A radical surgical procedure, an exenteration of the orbit and sinus followed by postoperative radiotherapy for a moderately differentiated tumor of the ethmoidal labyrinth spread to the orbit allowed achieving a positive treatment outcome, both in terms of local status (i.e., no tumor recurrence or regrowth) and disease process (no metastasis), over a 3-year follow-up in all the patients (100%). The decision of the extent of surgery should be made by a multispecialty team including an otorhinolaryngologist, eye cancer specialist and neurosurgeon.

Keywords: tumor of the ethmoidal labyrinth, exenteration of the orbit and sinus



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Received 24.10.2022

Accepted 12.12.2022 

Corresponding author: Yevcheva A. F., email: esebuat11@gmail.com

Author contribution: All authors participated in the conception of the article and in writing the manuscript. The final version of the manuscript has been approved by all authors, who in turn are solely responsible for submitting the final version for publication. 

Funding Sources: There are no external sources of funding.


Conflict of Interest Statement: The authors declare that they have no conflict of interest that could influence their opinion on the subject matter or materials described and discussed in this manuscript.