J.ophthalmol.(Ukraine).2021;2:31-35.
http://doi.org/10.31288/oftalmolzh2021231354
Received: 02 October 2020; Published on-line: 19 April 2021
Features of dry eye manifestations in patients with different durations of diabetes mellitus
I. F. Nabieva1, F. A. Khaidarova1, F. A. Bakhritdinova2, O. I. Oripov2
1 Republican Specialized Scientific and Practical Medical Center of Endocrinology; Tashkent (Uzbekistan)
1 Tashkent Medical Academy; Tashkent (Uzbekistan)
E-mail: okil.oripov@mail.ru
TO CITE THIS ARTICLE: Nabieva IF, Khaidarova FA, Bakhritdinova FA, Oripov OI. Features of dry eye manifestations in patients with different durations of diabetes mellitus. J.ophthalmol.(Ukraine).2021;2:31-35.http://doi.org/10.31288/oftalmolzh2021231354
Background: The risk of the development of proliferative diabetic retinopathy as well as abnormalities in the structure and/or function of the lacrimal functional unit significantly increases with an increase in diabetes mellitus duration, potentially leading to the development of dry eye.
Purpose: To assess the state of the lacrimal functional unit in diabetic patients with dry eye and different durations of diabetes.
Material and Methods: One hundred and twenty patients with both type 2 diabetes mellitus and dry eye disease were included in the study. Hemoglobin A1c levels and clinical manifestations of diabetic polyneuropathy and dry eye disease were comprehensively assessed.
Results: We found that diabetes duration plays a dominant role in the nature of the course of dry eye disease in patients with type 2 diabetes mellitus. The main features of manifestations of dry eye disease in patients with diabetes mellitus are the predominance of the subjective symptoms in those with shorter diabetes duration and the absence of complaints of eye dryness as well as the presence of objective structural changes in the lacrimal functional unit in those with longer diabetes duration.
Conclusion: Patients with long duration of diabetes mellitus have a latent course of dry eye disease and relatively severe structural abnormalities in the lacrimal functional unit.
Keywords: type 2 diabetes mellitus, diabetic polyneuropathy; dry eye disease
References
1.Azamatova GA, Aznabaev MT, Avkhadeeva SR. [Dry eye syndrome in patients with diabetes mellitus: prevalence, pathogenesis, clinical features. Meditsinskii vestnik Bashkortostana. 2018; 13(73):99-102.
2.Bikbov MM, Surkova VK. [Cornea and its changes in diabetes mellitus: the review]. Sakharnyi diabet. 2016;19(6):479-85. Russian.
3.Beckman KA. Characterization of dry eye disease in diabetic patients versus nondiabetic patients. Cornea. 2014; 8(33):851–84.
4.Stevenson W, Chauhan SK, Dana R. Dry eye disease: an immune-mediated ocular surface disorder. Arch Ophthalmol. 2012 Jan;130(1):90-100.
5.Achtsidis V, Eleftheriadou I, Kozanidou E, et al. Dry eye syndrome in subjects with diabetes and association with neuropathy. Diabetes Care. 2014;37(10):e210–e211.
6.Misra SL, Patel DV, McGhee CN, et al. Peripheral neuropathy and tear film dysfunction in type 1 diabetes mellitus. J Diabetes Res. 2014;2014:848659.
7.Balashevich LI, Brzhevskii VV, Izmailov AS, et al. Ocular manifestations of diabetes. Moscow: Medicina; 2004. Russian.
8.Zeng X, Lv Y, Gu Z. The Effects of Diabetic Duration on Lacrimal Functional Unit in Patients with Type II Diabetes. J Ophthalmol. 2019 Jan 10;2019:8127515
9.Yoon KC, Im SK, Seo MS. Changes of tear film and ocular surface in diabetes mellitus. Korean J Ophthalmol. 2004 Dec;18(2):168-74.
10.Neira-Zalentein W, Holopainen JM. Tervo TM, et al. Corneal sensitivity in diabetic patients subjected to retinal laser photocoagulation. Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):6043-9.
11.Pritchard N, Edwards K, Vagenas D, et al. Corneal sensitivity as an ophthalmic marker of diabetic neuropathy. Optom Vis Sci. 2010 Dec; 87(12):1003–8.
12.Eissa IM, Khalil NM, El-Gendy HA. A controlled study on the correlation between tear film volume and tear film stability in diabetic patients. J Ophthalmol. 2016;2016:5465272.
13.Najafi L, Malek M, Valojerdi AE, et al. Dry eye and its correlation to diabetes microvascular complications in people with type 2 diabetes mellitus. J Diabetes Complications. Sep-Oct 2013;27(5):459-62.
The authors declare no conflict of interest which could influence their opinions on the subject or the materials presented in the manuscript.