Received: 02 April 2020; Published on-line: 30 April 2020

Late immunocorrection after frontal orbital trauma surgery that involved the use of biocomposite

О.D. Bondarchuk1, 2, Cand Sc (Med); V.V. Kishchuk 1, Dr Sc (Med), Prof.; О.F. Melnykov 3, Dr Sc (Med), Prof.;  М.D. Tymchenko 3, Cand Sc (Biol); N.D. Didyk 2, MD

1 Pirogov National Medical University of Vinnytsia;  Vinnytsia (Ukraine)

2 Pirogov Regional Clinical Hospital of Vinnytsia;  Vinnytsia (Ukraine)

3 Prof. Kolomiichenko Institute of Otolaryngology, NAMS of Ukraine;  Kyiv (Ukraine)

E-mail:  eskulap20009@gmail.com

TO CITE THIS ARTICLE: Bondarchuk ОD, Kishchuk VV, Melnykov ОF, Tymchenko МD, Didyk ND.  Late immunocorrection after frontal rbital trauma surgery that involved the use of biocomposite. J.ophthalmol.(Ukraine).2020;2:56-59. http://doi.org/10.31288/oftalmolzh202025659


Purpose: To correct immune system deficiencies in patients with a problematic recovery course after frontal orbital trauma surgery that involved the use of SYNTEKIST biocomposite.

Material and Methods: Twenty facial bone trauma (FBT) patients with complicated wound healing in the late postoperative period were examined. The control group involved 10 healthy individuals. Patients of the rehabilitation treatment group were administered Imupret®, the commercial herbal medicinal product and an immunocorrective and antiphlogistic agent, and Eebisol, an IFN-γ inducer and repairing agent. Serum levels of immunoglobulin (Ig)M, IgE, interleukin (IL)-1β, IL-10, gamma interferon (IFN-γ), and transforming growth factor (TGF)-1β were measured.

Results: Two groups of patients who underwent FBT surgery that involved the use of biocomposite were identified. The group with a problematic late postoperative course exhibited stimulation of pro- and anti-inflammatory cytokines and absence of changes in serum levels of immunoglobulins and circulating immune complexes compared to controls and the group with uneventful late postoperative course. In addition, the group with a problematic late postoperative course exhibited decreased serum levels of TGF-β and IFN-γ, which may be considered as pathogenetically significant factors involved in regeneration processes. No humoral autoimmune response to connective tissue antigens was found.

Conclusion: Increased serum levels of pro- and anti-inflammatory interleukins and decreased serum levels of TGF-β and, especially, IFN-γ, are observed in patients with problematic regeneration. No humoral autoimmune response to connective tissue antigens was found in either group of patients with FBT. Stress mechanisms might be involved in decreased immunity levels in these patients.

Keywords: frontal orbital trauma, immunoglobulins, cytokines, growth factor, immune complexes, humoral autoimmune responses, SYNTEKIST biocomposite



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The authors certify that they have no conflicts of interest in the subject matter or materials discussed in this manuscript.