Relationship between electroretinogram records and clinical signs in patients with various stages of primary open-angle glaucoma
L.M. Stotska, Cand of Sc (Med)
I.B. Linnyk-Chokova, Cand of Sc (Med)
S.B. Slobodyanyk, Cand of Sc (Med)
V.L. Kushnir, MD
A.O. Nevska, MD
Filatov Eye Disease and Tissue Therapy Institute
Introduction. Lately, a much attention has been paid to studying the retina in patients with primary open angle glaucoma (POAG). The essence of the process has been reported to be an accelerated death of ganglion cells in the retina and retinal axons, comprising the optic nerve, as well as neuroglia, providing optic nerve repair, involved in the pathological process.
The purpose of the present paper was to study the relationship between electroretinogram records and clinical signs in patients with various stages of primary open-angle glaucoma.
Material and Methods. 358 eyes of 186 patients with POAG and patients with POAG to be confirmed underwent complex clinical and neurophysiological examination at SI “The Filatov Institute of Eye Diseases and Tissue Therapy”.
Results. It is known that negative a-wave potential displays response in photoreceptor cells of the outer retinal layer and positive b-wave characterizes bioelectrical activity of the second order neurons of the retina (bipolar cells with possible contributions of horizontal and amacrine cells) and Muller glia cells whilst 30 and more Hz stimulation can be responded by cones only. Therefore, according to our data, initial glaucoma patients have lesions in outer and inner retinal layers as early as initial stages of glaucomatous process. The most apparent pathological changes in neurophysiological process are observed in photoreceptor cells of the outer retinal layer, including cone elements of the retina.
Conclusion. As pathological process is growing, more correlations are observed; therefore, pathological changes affect corresponding retinal elements and result in a decrease of differential light sensitivity of the retina, central visual acuity defects, an increase of IOP, and a decrease of optic nerve excavation width; and this is the evidence of pathogenetic character of these neurophysiological alterations in the retina.
Key words: primary open-angle glaucoma, electroretinogram, photoreceptor cells, inner retinal layer
1.Zavgorodnyaya NV, Pasechnikova NV. [Primary glaucoma. A new look at an old problem]. Zaporozhzhye. 2010:192. Russian.
2.KachanT., Marchanka L., BirichТ., Dalidovich A., MushtinaT., Verenich A. Comparative study of the optical coherence tomography and scanning laser polarimetry in glaucomatous optic neuropathy diagnosis and monitoring. Oftalmologiia. Vostochnaia Evropa. 2014;4(23):186-91. Russian.
3.Stotska LM, Stotska LS. Peculiarities of chromatic optic canals activity at different stages of primary glaucoma. Oftalmol Zh. 2013;6:22-25. Russian.
4.Choplin NT, Lundy DS. [Glaucoma]. Moscow: Logosfera; 2011. 354 p. Russian.
5.Shamshinova AM, Andreeva TM. [Clinical physiology of vision]. Moscow; 2006. 956 p. Russian.
7.Ozturker Zeynep, Sezin Erkul, Dilek Turkmen, Kadir Eltutar. The relationship between central corneal thickness, topographic parameters of optic nerve head and retinal nerve fiber layer thickness in primary angle glaucoma. 11 th EGS Congress. Nice, 2014:139.
8.Valladares AM, Amoros NP, Cortes AC, Morollon JP, Moreno IF. Validity of ganglion cell–inner plexiform layer thickness measurement in the diagnosis of preperimetric glaucoma:correlation with retinal nerve fiber layer thickness. Glaucoma Unit of Albacete, Albacete – Spain. 11 th EGS Congress. Nice, 2014:133.
9.Ammari Wafa, Anis Mahmoud,Sameh Mbarek, Bechir Jelliti, Sana Kochtali,Riadh Messaoud,Moncef Khairallah. Epidemiology and factors of progression of open–angle glaucoma. CHU – Tunisia. 11 th EGS Congress. Nice. 2014. 37.
10.Wu DeZheng, Liu Yan Atlas of testind and clinical application for Roland Electrophysiolodiсal Instrument. Beigind science and technology Press: China; 2006.5–19