https://doi.org/10.31288/oftalmolzh201543537

Effect of photodynamic doses of laser irradiation on endogenous intoxication indices

F.A. Bakhritdinova, Dr. Sc. (Med), Prof., K.I. Narzikulova, Cand. Sc. (Med), Senior Lecturer, S.Sh. Mirrakhimova, Cand. Sc. (Med), Teaching Fellow

Ocular Disease Department, Tashkent Medical Academy, Tashkent, Uzbekistan

E-mail:  bakhritdinova@mail.ru

Background: One of the promising areas in ophthalmology is photodynamic therapy (PDT).

Purpose: To assess the effect of laser irradiation of the rat eye at the doses applied in PDT (without photosensitizer) on endogenous intoxication indices.

Materials and Methods: Fifty rats were used to investigate the effect of different modes of photodynamic irradiation of the rat eye on changes in endogenous intoxication indices over time.

Results: Exposure to 630-nm laser irradiation of 300-mJ pulsed mode (3 min) and 60-J photodynamic dose (PDD) mode (15 s) does not result in the development of endogenous intoxication. According to the literature, serum level of middle-weight molecules (MWM) is an integral marker of metabolic disorders of the body and can be used as evidence of the intensity of endogenous intoxication.

Conclusion: Exposure to 630-nm laser irradiation of 300-mJ pulsed mode (3 min) and 60-J PDD mode (15 s) does not result in the development of endogenous intoxication, making possible the application of these modes in practical ophthalmology. Because exposure to 890-nm laser irradiation of 300-mJ pulsed mode (3 min), and, especially, to 630-nm laser irradiation of 120-J PDD mode (30 s) results in the increased accumulation of MWM in circulating blood of animals, the eye should not be exposed to such irradiation doses.

Keywords: photodynamic therapy, endogenous intoxication, middle-weight molecules (MWM).

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