Oftalmol Zh.2015;1:134-139


Ciliary body and iris melanoma in the 4 y/o child 

N. F. Bobrova, V. V. Vit, T. A. Sorochinskaya, N. I. Bahmatskaya 

State Institution The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine; Odessa, (Ukraine)

Purpose: To analyze the rare clinical case of uveal melanoma in a 4 у/о child. 

Material and methods: Management of a 4 y/o child with uveal melanoma, 

Results: Melanoma of the ciliary body with spreading into the iris, anterior chamber angle and suspicion of intrascleral growth was diagnosed after complete clinical examination. According to the conclusion of the international consilium enucleation of the eyeball was performed. Pathomorphology diagnosis: ciliary body and iris melanoma of the mixed cellular type. Drainage zone blocks by melanin seeds. No external scleral layers and extrabulbar invasion. 

Conclusions: The presented clinical case suggests the possibility of uveal melanoma developing in young children. Pediatric ophthalmologists have to be more attentive to the pigmented lesions and don’t exclude the melanoma occurrence in children’s age. 

Key words: Ciliary body and iris melanoma, children’s age, enucleation. 


1.Avetisov ES, Kovalevskii EI, Khvatova AV. Guidelines for Pediatric Ophthalmology. M.:Meditsina; 1987. 440–50. 

2.Bobrova NF, Vit VV, Tronina SA. The case of amelanotic melanoma of the iris of the child. Oftalmol Zh. 2004;6:103–6. In Russian. 

3.Vit VV. Tumor pathology of visual organ. Odessa: Astroprint; 2009. 275–335. 

4.Kotelyanskii EO. Intraocular tumors. M.: Meditsina; 1974. 6–20. 

5.Maletskii AP. Modern methods of intraocular melanoma treatment. Methodological recommendations — 2013. Kyiv. 20 p. 

6.Terentieva LS. Intraocular tumors. Tumors of the eye, its adnexa and the orbit. K.: Zdorovya; 1978. 109–23. 

7.Terentieva LS, Vit VV, Polyakova SI. Prognostic value of the factor of secondary glaucoma in organ-preserving treatment of uveal melanoma. Oftalmol Zh. 2004;6:8–12. In Russian. 

8.Arun D. Singh, Carol L. Shields, Uveal Melanoma in Young Patients. Uveal Melanoma in Young Patients. 

9.Barr CC, McLean IW, Zimmerman LE. Uveal melanoma in children and adolescents. Arch Ophthalmol. 1981 Dec;99(12):2133–6. 

Crossref  PubMed 

10.Bhouri L, Lumbroso L, Levy C et at. Bilateral uveal melanomas. Five case reports. J Fr Ophtalmol. 2003 Feb; 26(2):149–53. 

11.Brodway D, Lang S, Harper J. Congenital malignant melanoma of the eye. Cancer. 1991 May 15;67(10): 2642–52 


12.Shields CL, Kaliki S, Arepalli S, et.al. Uveal melanoma in children and teenagers. Saudi J Ophthalmol. 2013 Jul;27(3):197–201. 

Crossref  PubMed 

13.Egan KM, Seddon JM, Glynn RJ et al. Epidemiologic aspects of uveal melanoma. Surv Ophthalmol. 1988 Jan-Feb;32(4):239–51. 


14.Grabowska A1, Abelarias J, Peralta J, et al. Uveal melanoma in a 19-month-old child. J AAPOS. 2011 Dec;15(6):606–8. 

Crossref   PubMed

15.Gray ME1, Shaikh AH, Corrêa ZM, et al. Primary uveal melanoma in a 4-year-old black child. J AAPOS. 2013 Oct;17(5):551–3. 

Crossref   PubMed 

16.Greer CH. Congenital melanoma of the anterior uvea. Arch Ophthalmol. 1966 Jul;76(1):77–8. 

Crossref  PubMed 

17.Hill JC, Stannard C, Bowen RM. Ciliary body malignant melanoma in a black child. J Pediatr Ophthalmol Strabismus 1991;28:38–40. 

18.Palazzi MA1, Ober MD, Abreu HF, Congenital uveal malignant melanoma: a case report. Can J Ophthalmol. 2005 Oct;40(5):611–5. 


19.Pogrzebielski A1, Or³owska-Heitzman J, Romanowska-Dixon B. Uveal melanoma in young patients. Graefes Arch Clin Exp Ophthalmol. 2006 Dec;244(12):1646–9. 

Crossref   PubMed 

20.Pukrushpan P, Tulvatana W, Pittayapongpat R. Congenital uveal malignant melanoma. J AAPOS. 2014 Apr;18(2):199–201.

Crossref   PubMed 

21.Reeh MJ, Petersen P, Kobrin JG, et. al. Malignant melanoma of choroid developing in the eye of a three-year-old boy. Ann Ophthalmol. 1979 Jan;11(1):57–70. 

22.Rosenbaum PS1, Boniuk M, Font RL. Diffuse uveal melanoma in a 5-year-old child. Am J Ophthalmol. 1988 Nov 15;106(5):601–6. 


23.Shields CL1, Kaliki S, Shah SU, et. al., Iris melanoma: features and prognosis in 317 children and adults. J AAPOS 2012 Feb; 16(1): 10–6. 

Crossref   PubMed

24.Shields CL1, Shields JA, Milite J, et al. Uveal melanoma in teenagers and children. A report of 40 cases. Ophthalmology. 1991 Nov;98(11):1662–6. 


25.Singh A. D. Bergman L., Seregard S. Uveal melanoma: epidemiologic aspects // Ophthalmol Clin North Am. 2005 Mar; 18(1): 75–84. 

Crossref   PubMed  

26.Singh AD, Shields CL, Shields JA, Uveal melanoma in young patients. T. Arch Ophthalmol. 2000 Jul;118(7):918–23. 

Crossref   PubMed 

27.Sun HP1, Lin Y2, Pan CW3 Iris color and associated pathological ocular complications: a review of epidemiologic studies.Int J Ophthalmol. 2014 Oct 18;7(5):872–8.