Oftalmol Zh.2014;6:106-112

https://doi.org/10.31288/oftalmolzh20146106112

Ultrastructural changes of the precrystalline membrane and anterior capsule in uveal cataracts in children

N. F. Bobrova, V. V. Vit, N. E. Dumbrova, A. N. Dembovetskaya, T. V. Romanova, N. I. Molchanyuk, E. L. Nesterets

Introduction. Despite the achievements of the pathophysiology, patoanatomii,biochemistry, cyto- and histology uveal cataract development mechanism is notfully understood. Uveal cataracts cataractogenesis characterized on the one hand changes necrotic epithelial cells and the activation of cellular metabolism of the capsule itself, and on the other hand the change of the capsular collagen production.

Both mechanisms affect the integrity of the lens capsule and the suction function of the lens epithelium, resulting in causing clouding of the lens.

Purpose. Investigate the ultrastructure of the epithelium and the anterior lens capsule during cataract complicated with chronic uveitis in children and to study its changes.

Material and Methods. Electron microscopy investigated four sites pupillary membrane and the anterior capsule of the lens removed from the children's eyes with uveal cataract of various etiologies. Two of the children was the etiology of rheumatoid uveitis, two others — viral.

Results. In all tested samples showed pronounced tissue degeneration and disintegration of the epithelium and the anterior lens capsule.

Conclusion. Based on the study can be assumed that on the background of chronic uveitis expressed on the one hand dystrophic and necrotic changes of the epithelial cells by activation of metabolism of cells of the capsule, and on the other hand, the changes of products kapsulnogo collagen. Both mechanisms violate the integrity Key woirk: cataract anteri0r capsuie  of the lens capsule suction function of the epithelium of the lens, resulting in calls 0f the lens corticosteroids chronic cataract, but these assumptions require longer and deeper study involving a large uveitis, children, experimental study. number of investigated with different types of uveitis.

References

1.Avetisov SE, Egorova EA. Ophthalmology: National guidance. M.: «GEOTAR-Media»; 2008. 721 p.

2.Basinskii SN, Egorov EA. Clinical lecture on ophthalmology. Textbook. M.: «GEOTAR-Media»; 2007. 40 p.

3.Bobrova NF, Dembovetska GM, Romanova TV, Nesterets OL. Method of surgical treatment of cataract complicated with chronic uveitis. Oftalmologiia. Vostochnaia Evropa. 2013;1(16):38-9.

4.Vit VV. The structure of human visual system. Odessa; 2003.

5.Guseva MP. Clinical and epidemiological features of uveitis in children. Vestn Oftalmol. 2004;1:15-8. Russian.

6.Drozdova EA. Uveitis in rheumatic diseases: clinics, diagnosis, immunopathogenesis and treatment: author's thesis for Candidate of Med Science. Moscow; 2006.

7.Ermakova NA. Classification and clinical assessment of uveitis. Klin. Oftalmologiia. 2003;4(4):146. Russian.

8.Ermakova NA. General concepts of the pathogenesis of uveitis. Russkii Med. Zhurnal. 2003;4(4):141-3. Russian.

9.Katargina LA, Khvatova AV. Endogenous uveitis in children and adolescents. Moscow. 2000.

10.Leus NF. Study of pathochemical and biophysical mechanisms of degenerative and inflammatory diseases of the eye. Novosti meditsyny I farmatsii. Oftalmologiia. 2011;363. Russian.

11.Pavlyuchenko KP, Kravtsova NV. Investigation of the role of free radical compounds in the pathogenesis of endog¬enous uveitis. Oftalmol Zh. 2006;1:44-6. Russian.

12.Panchenko NV, Bezdetko PA. Complications and results of uveitis treatment in children. Abstracts of II conference of children ophthalmology «Modern technologies of diag¬nosis and treatment of ocular pathology in children», the Crimea, Sudak. 2003.

13.Savko VV, Naritsyna NI. The main etiological forms of endogenous uveitis: clinical features, diagnosis, and treat¬ment. Oftalmol Zh. 2006;1:58- 62. Russian.

14.Senchenko NYa. Uveitis. Moscow; 2010.

15.Taylor D, Hoyt K. Paediatric Ophthalmology. Trans¬lated from English. Egorova EV, the Editor. Moscow, St.Petersburg; 2002.

16.Tretyak EB, Syroiedova ON. Modern views on the patho-genesis of autoimmune uveitis. Russkii Med. Zhurnal. 2003;4(4):144-5. Russian.

17.Khalpakhchyan LKh. Chronic uveitis in children: problems of diagnosis and treatment. Rossiiskii pediatrich. zhurnal. 2010;2:35- 42. Russian.

18.Andjelic S, Hawlina M. Cataractogenesis. Zdrav Vestn. 2012;81:I: 122- 32.

19.Heiligenhaus A, Heinz C. Use of Corticosteroids in children with uveitis. Uveitis. 2007:22.

20.Cunningham ET. Uveitis in children. Ocul.Immunol.Inflam. 2000;8(4).

21.Jancevski M, Stephen Foster C. Cataracts and Uveitis/ Maria Jancevski, Journal Issues. January, 2010;21(1):10-4.

22.Stunf S, Hawlina M. Ultrastructure of the anterior lens capsule and epithelium in intumescent white and uveitic cataracts. Programme 9 Slovenian Congress of Ophtal-mology with international participation. 28- 30 June 2012:311.