Oftalmol Zh. 2013;6:17-21.
Morphometric peculiarities of nervous fiber a layer thickness and disk of optic nerve in children with amblyopia and hypermetropic refraction
Boichuk IM, Jahnitsa EI
SI «The Filatov Institute of Eye Diseases and Tissue Therapy NAMS of Ukraine», Odessa Center of Eye Microsurgery, Kiev
The purpose of the study was to investigate morphometric peculiarities of the layer of the nervous fibres of the retina and optic nerve in children with amblyopia and hypermetropic refraction by means of the optical coherent tomography.
Material and methods. There were studied the parameters of the optic nerve, thickness of the layer of the nervous fibres in 149 children (298 eyes) aged 4—12 with amblyopia and hypermetropic refraction by means of the optical coherent tomography, of them there are investigated 84 (56.6 %) children with dysbinocular amblyopia; refraction amblyopia — 37(24.8 %); anisometropic amblyopia — 28 (18.8 %). The control group was made by 10 healthy children aged 6—8.
Results. There were established great values of size of the optic nerve disc area and thickness of the layer of the nervous fibres of amblyopic eye in comparison with a paired one. Reliably larger sizes of thickness of the layer of the nervous fibres in the lower and nasal sector in the amblyopic eyes in comparison with a paired one are revealed. The results received can be evidence of abnormal postnatal apoptosis in children in refraction and anisometropic amblyopia with hypermetropic refraction.
Key words: amblyopia, hypermetropic refraction, optical coherent tomography, the optic nerve, nervous fiber layer thickness
1.Avetisov ES. Strabismic amblyopia and its treatment. M.: Meditsina; 1968. 208 p.
2.Avetisov ES, Kashchenko TP, Shamshinova AM. Visual functions and their correction in children. M.: Meditsina; 2005. 872 p.
3.Boichuk IM, Ivanitskaya EV. Results of application of optical coherence tomography of the retina and optic nerve in children with monolateral amblyopia. Current problems of medical and social rehabilitation of children with disabling ocular pathology: III Scientific Conference with international participation: Abstracts and lectures. Evpatoria. 4-6 October 2006. 59-60. Russian.
4.Boichuk IM, Ivanitskaya EV. The results of optical coherence tomography of the retina and optic nerve in children with amblyopia of the hogh degree.Oftalmol Zh. 2006; 3: 46-9. Russian.
5.Botabekova TK, Kurgambekova NS. Optical coherence to-mography in the diagnosis of amblyopia. Vestn oftalmol. 2005; 121(5): 28-9. Russian.
6.Shamshinova AM, Yakovleva AA, Romanova EV. Clinical physiology of vision. M.: NMF MNB, 2002. 672 p.
7.Altintas O, Yuksel N, Ozkan B, Caglar Y. Thickness of the retinal nerve fiber layer, macular thickness, and macular volume in patients with strabismac amblyopia. J Pediatr Ophthalmol Strabismus. 2005; 42(4): 216-21.
8.Al-Haddad C. E, El Mollayess G. M, Cherfan C. G. et al. Retinal nerve fiber layer and macular thickness in amblyo-pia as measured by spectral-domain optical coherence to-mography Br J Ophthalmol. 2011; 3: 11.
9.Baddini-Caramelli C, Hatanaka M, Polati M et al. Thich-ness of the retinal nerve fiber layer in amblyopic and normal eyes: a scanning laser polarimetry study. J AAPOS. 2001: 5: 82-4.
10.Bozkurt B, Irkec, Orhan M et al. Thickness of retinal nerve fiber layer in patients with anisometopic and strabismic amblyopia Strabismus. 2003; 11: 1-7.
11.Duranoglu Y. Optic nerve head topographic analysis and retinal nerve layer thickness in strabismic and anisometropic amblyopia. Ann ophthalmol (Skokie). 2007; 39: 291-5.
12.Kee SY, Lee SY, Lee Y C. Thicknesses of the fovea and reti-nal nerve fiber layer in amblyopic and normal eyes in chil-dren. Korean J Ophthalmol. 2006; 20(3): 177- 81.
13.Lempert P. Optic nerve hypoplasia and small eyes in pre-sumed amblyopia. J AAPOS. 2000; 4: 258-66.
14.Lempert P. Retinal Area and Optic disk rim area in Amly-opic, Fellow, and Normal Hyperopic Eyes: A Hypothesis for Decreased Acuity in Amblyopia Ophthalmology. 2008; 115(12): 2259-61.
15.Miki A, Shirakashi M, Yaoeda K, Kabasava Y. Retinal nerve fiber layer thickness in recovered and persistent amblyopia Clin Ophthalmol. 2010 ; 4: 1061-4.
16.Repka M. X, Goldenberg-Cohen N, Edwards AR. Retinal nerve fiber layer thickness in amblyopic eyes. Am J Oph-thalmol. 2006; 142(2): 247- 51.
17.Savini G, Zanili M, Carelli V. Correlation between retinal nerve fibre layer thickness and optic nerve head size: an op-tical coherence tomography study. Br J Ophthalmol. 2005; 89: 489- 92.
18.Yen MY, Cheng CY, Wang AG. Retinal nerve fiber layer thickness in unilateral amblyopia. Invest Ophthalmol Vis Sci. 2004; 45(7): 2224- 30.
19.Yoon SW, Park WH, Baek SN, Kong SM. Thickness of macular retinal layer and peripapillary retinal nerve fiber layer in patients with hyperopic anisometropic amblyopia. Korean J Ophthalmol. 2005; 19(1): 62-7.