Oftalmol Zh. 2013; 5: 51-6.
https://doi.org/10.31288/oftalmolzh201355156
Clinical and neurofunctional criteria for prognosing the development of primary open angle glaucoma
Stotska LM
Ivano-Frankivsk, Ukraine
Introduction. The etiology and pathogenesis of primary open-angle glaucoma remain controversial, causing considerable difficulties in its early diagnosis. Purpose. To study the clinical and neurofunctional criteria for prognosing the development of primary open-angle glaucoma (POAG)
Material and Methods. A clinical and functional examination was made in 119 patients with primary open angle glaucoma, the average age (51.8 + 3.2) years old; 46.8 % male and 53.2 % female, and 30 patients of a study group without POAG with diseases as follows: vegetative — vascular dystonia, migraine, hypertension, hypotension; mean age 52.4 + 3.1, 48.3 % and 51.7 % males and females respectively. We used neurophysiological methods: visual sensory-motor reaction according to standard procedure, the critical flicker fusion frequency (CFFF) was studied using the diagnostic module ophthalmic stimulator KNSO2— 91 «phosphene», allowing to detect functional changes in the visual analyzer at its different levels.
Results. We received priority data regarding aspects of neurofunctional status in patients with primary open angle glaucoma: a statistically significant changes in the imbalance between excitation and inhibition, namely, the increase in the difference values of the latent periods of simple and complex visual sensorimotor reactions, reducing the lability of the nervous system that meet the clinical and morphological changes of glaucomatous optic neuropathy at appropriate stages.
Conclusions. With the help of multivariate analysis it was established clinical criteria of neurofunctional early diagnosis and prognosis of primary open angle glaucoma: an increase in the difference between the latent periods of simple and complex visual sensorimotor reactions exceeds the standard value of 145 ms by 20 % or more; a decrease of the lability of the nervous system (in blue) from 31.01 Hz when volume is reduced neuroretinal rim from 0.36 mm 3.
Key words: primary open angle glaucoma, nervous system lability, visual sensory-motor reactions
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