Full text Pdf 

http://doi.org/10.31288/oftalmolzh2011248

CLINICAL PECULIARITIES AND PROGNOSIS OF HLA-B27 ASSOCIATED ANTERIOR UVEITIS

Kopayenko A. I., Zhaboedov G. D., Ivanova N. V.

Simferopol, Kiev, Ukraine

The clinical peculiarities and prognosis of HLA-B27 positive anterior uveitis (AU) were compared with HLA-B27 negative AU. 35 patients with HLA-B27 negative, idiopathic AU (group I) and 40 HLA-B27 positive AU patients (group II) were studied. HLA-B27 positive group was further divided into 23 patients with associated systemic disease (seronegative spondyloarthropathy) (group IIA) and 17 patients without associated systemic diseases (group IIB). Significantly more severe anterior chamber inflammation in the anterior chamber cells and hypopyon formation was observed with higher frequency of AU attacks (p<0.05) in the HLA-B27 positive group than in the HLA-B27 negative group. Macular thickness (> 200 mcm) was 1.5 times more frequent in the patients of group II than in the patients of group I (p<0.05). Visual acuity was by 0.2 higher in HLA-B27 positive AU (p<0.05).

References

1. Ваничкин А. А., Шпак Н. И. Нарушения иммунологического статуса больных эндогенными увеитами и возможный путь их медикаментозной коррекции // Офтальмол. журн. — 1982. — № 1. — С.10-13.

2.Разумова И. Ю., Воробьева О. К., Годзенко А. А. Диагностика и лечение ИЬА-В27-ассоциированных увеитов // Вестник офтальмол. — 2009. — № 3. — С.15-18.

3.Разумова И. Ю., Годзенко А. А. Н1_А-В27-ассоциированные увеиты // Вестник офтальмол. — 2009. — № 4. — С.46- 50.

4.Chang J. H., Wakefield D. Uveitis: a global perspective // Ocul Immunol Inflamm. — 2002. — Vol.10. — P.263- 79.
Crossref

5.Chang J. H., McCluskey P. J., Wakefield D. Acute anterior uveitis and HLA-B27 // Surv Ophthalmol. — 2005. — Vol.50. — P.364- 88.
Crossref

6.Deschenes J., Murray P. I., Rao N. A., Nussenblatt R B. International Uveitis Study Group (IUSG): clinical classification of uveitis // Ocul Immunol Inflamm. — 2008. — Vol.16, № 1. — P.1-2.
Crossref

7.Jabs D. A., Nussenblatt R. B., Rosenbaum J. T. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop // Am J Ophthalmol. — 2005. — Vol.140, № 3. — P. 509- 516.
Crossref

8.Linssen A., Meenken C. Outcomes of HLA-B27-positive and HLAB27-negative acute anterior uveitis // Am J Ophthalmol. — 1995. — Vol.120. — P.351- 361.
Crossref

9.Monnet D., Breban M., Hudry C., Dougados M., Brezin A. P. Ophthalmic findings and frequency of extraocular manifestations in patients with HLA-B27 uveitis: a study of 175 cases // Ophthalmology. — 2004. — Vol.111. — P.802- 809.
Crossref

10.Pathanapitoon K., Suksomboon S., Kunavisarut P., Ausayakhun S., Wattananikorn S., Leetrakool N., Rothova A. HLA-B27-associated acute anterior uveitis in the University Referral Centre in North Thailand: clinical presentation and visual prognosis // Br J Ophthalmol. — 2006. — Vol.90. — P.1448- 1450.
Crossref

11.Power W. J., Rodriguez A., Pedroza-Seres M., Foster C. S. Outcomes in anterior uveitis associated with the HLA-B27 haplotype // Ophthalmology. — 1998. — Vol.105. — P.1646-1651.

12.Rothova A., van Veenedaal W. G., Linssen A., Glasius E., Kijlstra A., de Jong P. T. Clinical features of acute anterior uveitis // Am J Ophthalmol. — 1987. — Vol.103. — P.137-145.

13.Tuncer S., Adam Y. S., Urgancioglu M., Tugal-Tutkun I. Clinical features and outcomes of HLA-B27-positive and HLA-B27-negative acute anterior uveitis in a Turkish patient population // Ocul Immunol Inflamm. — 2005. — Vol.13. — P.367- 73.

14.Wakefield D., Easter J., Penny R. Clinical features of HLA-B27 anterior Uveitis // Clin Experiment Ophthalmol. —1984. — Vol.12. — P.191-196.