Oftalmol Zh.2010;6:71-76.

http://doi.org/10.31288/oftalmolzh201067176

PECULIARITIES OF CATARACT DEVELOPMENT IN RABBITS WITH EXPERIMENTAL DIABETES

Leus N. F., Ben Abdallah Anis Ben Slimane Odessa, Ukraine

There were studied signs of development of light cataract in animals with modeled diabetes. The experimental studies made on 42 rabbits established that development of the diabetic process is not accompanied by occurrence of the pathological changes in the lens. At the same time there was established reliable signs of lens opacity and development of the cataract process under the conditions of diabetes developed in animals exposed to light of high intensity. On this basis the authors consider presence of diabetes as a probable cocataractogenous factor.

 

References

1.Бабижаев М. А., Шведова А. А., Архипенко Ю. В. Накопление продуктов перекисного окисления липидов в хрусталике при катаракте //Бюл. экспер. биол. — 1985. — № 9. — С. 299- 301.

2.Веселовская 3. Ф., Боброва Н. Ф., Вит В. В. Катаракта //Киев: Книга плюс. — 2002. — 208 с.

3.Воскресенская Л. К. Патогенез и лечение старческой и диабетической катаракты: Автореф. дисс. ... докт. мед. наук: 14.00.16, 14.00.08 / Российский Университет дружбы народов. — М., 1993. — 32 с.

4.Леус Н. Ф. О пусковых механизмах катарактогенеза // Офтальмол. журн. — 1985. — № 7. — C. 430- 434.

5.Ayala M., Michael R., Soderberg P. Influence of exposure time for UV-radiation induced cataract // Invest. Ophthalmol. Vis. Sci. —  2000. —  Vol. 40 (1138). — P. 11-19.

6.Balasubramanian D. Ultraviolet radiation and cataract //J Ocul Pharm Ther. — 2000. — Vol. 81 (3). — P. 498- 501.

7.Barber G. W. Free amino acids in senile cataractous lenses: possible osmotic etiology //Invest. Ophthalm. — 1968. — Vol. 7 (5). — P. 564- 583.

8.Beebe D. C. Nuclear cataracts and nutrition: Hope for the intervention — early and late life //Invest. Ophthalmol. Vis. Sci. — 1998. — Vol. 39 (9). — P. 1531- 1534.

9.Bunce G., Kinoshita J. Nutritional factors in cataract // Ann. Rev. Nutr. — 1990. — Vol. 10. — P. 233- 254.

10.Chen T. T., Hockwin 0., Eckerskom U. et al. Cataract and health status. A case — control study revisited //Dev. Ophthalmol. — 1989. — Vol. 17. — P. 6-12.

11.Cumming R. G., Mitchell P., Smith W. Diet and cataract //Ophthalmology. — 2000. — Vol. 107. — P. 450- 456.

12.Jery I., Boisten V., Lupasco V. Biochemical aspects in the pathogenesis of senile cataract //Oftalmologia. — 1997. — Vol. 41 (3). — P. 207- 208.

13.Knudtson M. D., Klein B. E., Klein R. Age-related eye disease, quality of life, and functional activity //Arch Ophthalmol. — 2005. — Vol. 123 (6). — P. 807- 814.

14.Korlimbinis A., Aquilina J. A., Truscott J. W. Protein-bound and free UV filters in cataract lenses. The concentration of UV filters is much lower than in normal lenses //Exp. Eye Res. — 2007. — Vol. 85. — P. 219-225.

15.Laurent M., Kern P., Regnault F. Transport of amino acids into the lens in the course of experimental diabetic cataract //Ophthalm. Res. — 1972. — Vol. 4. — P. 114-121.

16.Leus N. F Lens coenzymes and cataract formation //Lens and Eye Toxicity Res. — 1991. — Vol. 283 (8). — P. 1113-1119.

17.McCarty C. A., Taylor H. R. The genetics of cataract // Invest. Ophthalmol. Vis. Sci. — 2001. — Vol. 42 (8). — P. 1677- 1678.

18.Meyer C. H., Secundo W. Nutritional supplementation to prevent cataract formation //Dev Ophthalmol. — 2005. — Vol. 38. — P. 103-119.

19.Mitchell P., Smith W., Cumming R. G. Nutritional factors in the development of age-related eye disease //Asia Pac J Clin Nutr. — 2003. — Vol. 12. — Suppl. S5.

20.Reyk D. M. The retina: oxidative stress and diabetes / D. M. Reyk, M. C. Gillies, M. J. Davies // Redox Rep. — 2003. — Vol. 8 (4). — P. 187- 192.

21.Robman L. D., Taylor H. External factors in the development of cataract //Eye. —  2005. — Vol. 19 (10). — P. 1074- 1082.

22.Stitt A. W. Advanced glycation and retinal pathology during diabetes / A. W. Stitt, T. M. Ccurtis // Pharmacol. Rep. — 2005. — Vol. 57. — P. 156- 168.