http://doi.org/10.31288/oftalmolzh20102810

SIGNIFICANCE OF VITREOUS FLYUOREMETRI FOR EARLY DIAGNOSTIC OF NONPROLIFERATIVE DIABETIC RETINOPATHY

V. O. Naumenko

Purpose. Improve early diagnostic of diabetic retinopathy (DRP) by studying the state of blood-retinal barrier with vitreous fluorometry.

Materials and methods. To explore the possibility of vitreous fluorometry in the early diagnostic of initial stage of nonproliferative DRP studied volunteers with no signs of eye diseases and diabetes mellitus patients with early nonproliferative DRP.

Results. Level vitreous fluorescence at the 5th and 30th minute significantly higher in patients with early nonproliferative DRP than in healthy volunteers. Raising of vitreous fluorescence at 5th minute more than 0.8 ng/ml, and 30th minute of a 3.4 ng/ml indicates the presence in patients with diabetes early nonproliferative stage of diabetic retinopathy.

Conclusion. There was developed the mathematical model for the differential diagnosis of the presence or absence of nonproliferative DRP according to state of blood-retinal barrier.

 

References

1.Вит В. В. Строение зрительной системы человека: Уч.пос. — Одесса: Астропринт, 2003. — 664 с.

2.Sander В., Larsen M., Moldow В., Lund-Andersen H. Diabetic macular oedema: passive and active transport of fluorescein through the  blood-retina barrier // Invest.Ophthalmol.Vis.Sci. — 2001. — Vol.42, № 2. — P.433-438.

3.Sander В., Larsen M., Engler C., Storm C., Moldow В., Larsen N., Lund-Andersen H. Diabetic macular oedema: a comparison of vitreous fluorometry, angiography, and retinopathy //Br. J. Ophthalmol. — 2002. — Vol.86, № 3. — P.316-320.
Crossref

4.Vinores S. A. Assessment of blood-retinal barrier integrity //Histol. Histopathol. — 1995. Vol.10. — P.141-154.