Oftalmol Zh.2009;3:41-45.

http://doi.org/10.31288/oftalmolzh200934145

DETERMINING OF DEGREE OF DISTURBANCE OF HEMATORETINAL BARRIER ASSOCIATED WITH DIABETIC RETINOPATHY BY FLUOROMETRY OF THE VITREOUS

Pasechnikova N. V., Naumenko V. A., Kushnir N. N.

Odessa, Ukraine

There were examed 10 healthy people without eye pathology and 108 patients (130 eyes) with diabetes mellitus and different stages of DR according WHO classification of DR. 12 patients had diabetes mellitus type I, other — type II.

Of the total number of studied eyes are four classes of disturbance of hematoretinal barried (HRB) were determined.

Quantitative analysis of data of fuorometry of the vitreous can be used in assessing of degree of disturbance of HRB associated with diabetic retinopathy. The state of HRB according to the fluorometry of the vitreous closely associated with the clinical stage of DR (%2 = 153,9; p = 0,0001). In severe nonproliferative DR fluoromentry of the vitreous according to data provided varying degrees of disturbance of the functions of the HRB. Determination of disturbance of the HRB can be useful in determining of the indications for laser coagulation of the retina in DR patients.

 

References

1.Cunha-Vaz J. G. The blood-ocular barriers: past, present, and future // Doc. Ophthalmol. —   1997. — Vol. 93. — P. 149-157.

CrossRef   PubMed

2.Dvorak H. F., Brown L, F., Detmar M., Dvorak A. M. Vascular premeability factor / vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis // Am. J. Pathol. — 1995. — Vol. 146. — P. 1029-1039.

3.Вит В. В. Строение зрительной системы человека: Уч. поб. — Одесса: Астропринт, 2003. — 664 с.

4.Qaum Т., Xu Q., Joussen A. M., Clemens M. W. et al. VEGF-initiated blood-retinal barrier breakdown in early diabetes // Invest. Ophthalmol. Vis. Sci. —  2001. — Vol. 42. — P. 24-8-2413.

5.Sander B., Larsen M., Moldow B., Lund-Andersen H. Diabetic macular oedema: passive and active transport of fluorescein through the blood-retina barrier // Invest. Ophthalmol. Vis. Sci. — 2001. — Vol. 42, № 2. — P. 433-438.

6.Wilkinson C. P., Ferris F. L. 3rd, Klein R. E. et al. The Global Diabetic Retinopathy Project Group: Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales // Ophthalmology. — 2003. — Vol. 110. — P. 1677-1682.

CrossRef  

7.Пасечникова Н. В., Науменко В. А., Зборовская А. В. и др. Состояние гематоретинального барьера при диабетической ретинопатии по данным флюорометрии // Офтальмол. журн. — 2008. — № 5. — С. 4-7.

8.Вит В. В., Буйко А. С., Драгомирецкая Е. И. Оценка степени злокачественности увеальной меланомы на основе использования кластерного анализа // Офтальмол. журн. — 2004. — № 6. — С. 18-22.

9.Dragomiretskaya E., Pasechnikova N., Katsan S. Cluster analysis for classification of Age-related Maculopathy (ARM) considering clinical and Optical Coherence Tomography data // 104th DOG Annual Meeting 21-24.09.2006, Berlin.

10.Vinores S. A. Assessment of blood-retinal barrier integrity // Histol. Histopathol. — 1995. — Vol. 10. — P. 141-154.