Changes in clinical condition of the eye and in parameters of cell and humoral immunity in iridocyclitis patients under the influence of anti-viral allokin-alpha  
N.V. Konovalova, Dr. Sc. (Med.)
N. I. Khramenko, Cand. Sc. (Med.)
L. N. Velichko, Cand. Sc. (Med.)
A. Ia. Novik, Cand. Sc. (Med.)   
SI “Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine”
Odessa, Ukraine
Introduction. Iridocyclitis, inflammatory eye disease of the uvea, is a topical issue not only in clinical but social regard, considering its high prevalence and disability rates.
Purpose. To study changes in the clinical condition of the eye and the state of cellular and humoral immunity in iridocyclitis patients under the influence of allokin-alpha anti-viral drugs.
Material and Methods. We observed 41 patients (41 eyes) with acute and chronic iridocyclitis who underwent anti-viral allokin-alpha treatment at Inflammatory Eye Pathology Department at SI “The Filatov Institute of Eye Diseases and Tissue Therapy”.
Results. Over the treatment course we observed a significant increase in immunoregulatory index from 1.16% to 2.00%; a relative T-lymphocyte count increased from 38.2±0.5% to 63.4±1.2% and a relative CD-19 lymphocyte count decreased from 24.4% to 21.8%, which reached normal parameters at 18 days after treatment onset. The treatment resulted in VA improvement.
Conclusions. Using allokin-alpha anti-viral drug enables to raise treatment success in viral iridocyclitis patients and to improve VA against the background of inflammatory process reduction.
Key words: iridocyclitis, allokin-alpha        
1.    Barinskii IF. [Herpesviral infections - immunodeficient diseases of the XXI century. Current issues of herpesviral infections]. 2004:5-7. Russian.
2.    Guliieva M. [Experimental and clinical studies of Oftalmoferon eye drops in the herpetic keratitis treatment]. Author’s thesis for Cand. Sc. (Med.). 14.00.08 Ophthalmology. M.; 2006. 30 p. Russian.  
3.    Degtyarenko TV. [Adaptive significance of immune homeostasis in eye diseases]. Oftalmol Zh. 1997;1:1–4. Russian.
4.    Drozdova EA, Tarasova LN, Teplova SN, Alekhina TV. [Immunological features of uveitis in systemic diseases]. Vestn Oftalmol. 2004;4:24–6. Russian.
5.    Zainutdinova GKh, Malkhanov VB, Shevchuk NE. [Features of systemic and local cytokine production in rheumatoid uveitis]. Tsitokiny i vospaleniie. 2008;7(2):52–5. Russian.
6.    Исаков В.А. Герпеcвирусные инфекции человека / В.А. Исаков, Е.И. Архипов, Д.В. Исаков // Руководство для врачей . — СПб.:СпецЛит., 2006. — 303 с.
7.    Metelitsyna IP, Levitska GV, Ghaffari Sahbi ben Mohamed Moncef. [The level of cytokines in intraocular fluids in patients with rhegmatogenous retinal detachment]. Odeskyi Med. Zhurnal. 2011; 4(126):37–9. Ukrainian.
8.    Sukhina LA, Lysenko AG, Yulish ME. [Optimizing the diagnosis and treatment of chronic recurrent uveitis in children caused by persistent intracellular infections]. Oftalmologiia. Vostochnaia Evropa. 2014;2(21):20–6.] Ruaaian.
9.    Khokkanen VM, Solovieva MV, Bataiev VM, Ionova OG. [Investigation of the role of cytokines in the course of tuberculous uveitis]. Collection of papers of scientific practical conference in ophthalmosurgery «East-West», 13–14 May 2011. Ufa, 2011. 350–352. Russian.
10.    Shaimova VA. [The role of inflammatory cytokines in eye diseases]. (Litereature review). Oftalmokhirurgiia i terapiia. 2004;4(3):30–2. Russian.
11.    Shishkin MK, Isakov VA, Iermolinko DK. Selected issues of infectious patient therapy: Guidance for physicians. SPb.: Foliant; 2005. 636-64. Russian.  
12.    Groot-Mijnes JDF, Groot-Mijnes L Visser, Zuurveen S et al. Identification of new pathogens in the intraocular fluid of patients with uveitis. Am. J. Ophthalmol. 2010;150 (5):628-36.
Crossref   Pubmed
13.    Plskova J, Greiner K, Forrester JV. Interferon- as an effective treatment for noninfectious posterior uveitis and panuveitis. Am. J. Ophthalmol.2007;144: 55-61.
Crossref   Pubmed
14.    Takase H, Sugita S, Taguchi C et al. Capacity of ocular infiltrating T helper type 1 cells of patients with non-infectious uveitis to produce chemokines. Br. J. Ophthalmol.2006;90:765-8.
Crossref   Pubmed